AI and Metabolic Modeling Lab

Roell Research Group - University of Hawaiʻi at Mānoa


The Roell lab aims to advance the process of industrial fermentation, a method widely used to produce valuable goods such as pharmaceuticals, vitamins, and polymers. While this process is sustainable and provides a stable supply chain for essential materials, lengthy and costly R&D phases pose significant barriers to market entry. To overcome this challenge, our research focuses on the development of tools to leverage bioreactor operations, fermentation results, and omics data to generate actionable insights. The platforms we develop not only assist in large-scale data generation but also explore novel applications that will allow the field to realize the full potential of synthetic biology.


Garrett Roell is an Assistant Professor in the College of Tropical Agriculture and Human Resources (CTAHR) in the Department of Molecular Biosciences & Bioengineering at the University of Hawaiʻi at Mānoa.

Previously, Garrett earned his Ph.D. at Washington University in St. Louis in Yinjie Tang’s Group. While working on his degree, Garrett earned a DOE Office of Science Graduate Student Research Award that allowed him to work at Lawrence Berkeley National Lab with Hector García Martín.


Zhengyang Xiao, Wenyu Li, Hannah Moon, Garrett W. Roell*, Yixin Chen*, and Yinjie J. Tang*

ACS Synthetic Biology Cover

Garrett W. Roell, Christina Schenk, Winston E. Anthony, Rhiannon R. Carr, Aditya Ponukumati, Joonhoon Kim, Elena Akhmatskaya, Marcus Foston, Gautam Dantas, Tae Seok Moon, Yinjie J. Tang, Hector García Martín

ACS Synthetic Biology Cover

Garrett W. Roell, Ashik Sathish, Ni Wan, Qianshun Cheng, Zhiyou Wen, Yinjie J. Tang, Forrest Sheng Bao

Biochemical Engineering Journal Cover

Garrett W. Roell, Rhiannon R. Carr, Tayte Campbell, Zeyu Shang, William R. Henson, Jeffrey J.Czajka, Hector García Martín, Fuzhong Zhang, Marcus Foston, Gautam Dantas, Tae Seok Moon, Yinjie J.Tang

Metabolic Engineering Journal Cover

Garrett W. Roell, Jian Zha, Rhiannon R. Carr, Mattheos A. Koffas, Stephen S. Fong, and Yinjie J. Tang

Microbial Cell Factory Journal Cover


The Roell lab is looking for students at all levels (undergraduates, masters, and Ph.D. students). If you are interested in conducting research at the intersection of synthetic biology and AI, please contact Garrett directly at

Roell Research Group
St John Plant Science Lab
University of Hawaiʻi at Mānoa
3190 Maile Way, 2nd Floor
Honolulu, HI 96822